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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DYRK2 All Species: 45.15
Human Site: S385 Identified Species: 70.95
UniProt: Q92630 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92630 NP_003574.1 601 66652 S385 R V Y T Y I Q S R F Y R A P E
Chimpanzee Pan troglodytes XP_509205 601 66595 S385 R V Y T Y I Q S R F Y R A P E
Rhesus Macaque Macaca mulatta XP_001117134 601 66643 S385 R V Y T Y I Q S R F Y R A P E
Dog Lupus familis XP_538273 601 66656 S385 R V Y T Y I Q S R F Y R A P E
Cat Felis silvestris
Mouse Mus musculus Q5U4C9 599 66538 S383 R V Y T Y I Q S R F Y R A P E
Rat Rattus norvegicus Q4V8A3 586 65492 S371 K L Y T Y I Q S R F Y R A P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511087 546 60615 L354 M P I D M W S L G C I L A E L
Chicken Gallus gallus Q5ZIU3 526 59419 L340 L G C I L A E L L T G Y P L L
Frog Xenopus laevis NP_001088793 567 63329 S352 R V Y T Y I Q S R F Y R A P E
Zebra Danio Brachydanio rerio NP_001038298 587 65453 S372 R V Y T Y I Q S R F Y R A P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P83102 828 92722 S439 R I Y T Y I Q S R F Y R A P E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001023208 796 87422 F608 S G I K V I D F G S S C F D D
Sea Urchin Strong. purpuratus XP_799140 561 63192 S356 R I Y T Y I Q S R F Y R A P E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51566 467 54180 I281 N L P K S S A I K L I D F G S
Baker's Yeast Sacchar. cerevisiae P14680 807 91227 S533 T V Y T Y I Q S R F Y R A P E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 99.6 98.3 N.A. 97 59.7 N.A. 78.6 81.3 64.5 83.6 N.A. 43.3 N.A. 45.7 63.7
Protein Similarity: 100 98.8 99.8 99 N.A. 98.5 71.8 N.A. 83 84.5 75 89.8 N.A. 54.9 N.A. 55.6 73.5
P-Site Identity: 100 100 100 100 N.A. 100 86.6 N.A. 6.6 0 100 100 N.A. 93.3 N.A. 6.6 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 6.6 100 100 N.A. 100 N.A. 13.3 100
Percent
Protein Identity: N.A. N.A. N.A. 21.3 27.2 N.A.
Protein Similarity: N.A. N.A. N.A. 36.6 41.2 N.A.
P-Site Identity: N.A. N.A. N.A. 0 93.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 7 0 0 0 0 0 80 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 7 0 7 0 0 0 % C
% Asp: 0 0 0 7 0 0 7 0 0 0 0 7 0 7 7 % D
% Glu: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 74 % E
% Phe: 0 0 0 0 0 0 0 7 0 74 0 0 14 0 0 % F
% Gly: 0 14 0 0 0 0 0 0 14 0 7 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 14 14 7 0 80 0 7 0 0 14 0 0 0 0 % I
% Lys: 7 0 0 14 0 0 0 0 7 0 0 0 0 0 0 % K
% Leu: 7 14 0 0 7 0 0 14 7 7 0 7 0 7 14 % L
% Met: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 7 7 0 0 0 0 0 0 0 0 0 7 74 0 % P
% Gln: 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 % Q
% Arg: 60 0 0 0 0 0 0 0 74 0 0 74 0 0 0 % R
% Ser: 7 0 0 0 7 7 7 74 0 7 7 0 0 0 7 % S
% Thr: 7 0 0 74 0 0 0 0 0 7 0 0 0 0 0 % T
% Val: 0 54 0 0 7 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 74 0 74 0 0 0 0 0 74 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _